Oct Angiography Changes After Local Anesthesia in Cataract Surgery

N/ANot Yet RecruitingNCT07298746

Sohag University100 enrolled

Overview

Assessement of retinal microvasculature detected by OCT-angio after peribulbar \&retrobulbar anesthesia in cases undergoing cataract surgery .

prospective , interventional,comparative , clinical study utilizing a pre-post, within-subject design ,which will be conducted in the Department of Ophthalmology ,Sohag University Hospital ,Egypt. Optical coherence tomography angiography (OCTA) will be performed before and after the administration of retrobulbar and peribulbar local anesthesia in the same cohort of patients, in order to evaluate the immediate effects of the anesthetic intervention on retinal microvascular parameters.the study will be conducted on patients aged 40-80 years with elective cataract surgery requiring regional block.the study will be divided into two main groups : 1. Group with peribulbar anesthesia injection. 2. Group with retrobulbar anesthesia injection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

100

Conditions

OCTA Changes With Local Anesthesia

Interventions

Local Anesthesia (peribular injection of both lidocaine 2 % and hyaluronidase 150IU\ML)DRUG

peribular injection of both lidocaine 2 % and hyaluronidase 150IU\\ML

Local Anesthesia (peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML)DRUG

peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\\ML

Local Anesthesia (retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\ML)DRUG

retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\\ML

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients aged 40-80 years. 2. patients with elective cataract surgery requiring regional block. Exclusion Criteria: * 1.Allergy to study drugs. 2. Media opacities affecting OCT imaging (corneal pathologies, dense cataracts, vitreous. opacities, etc). 3. Patients with any other retinal vascular diseases (retinal vein occlusion, central serous chorioretinopathy, age-related macular degeneration, etc). 4\. Patients who have had previous intravitreal injections or Laser treatment. 5. Patients who underwent previous vitreoretinal surgeries. 6. Patients with uncontrolled glaucoma or ocular inflammations (eg: vitritis). 7.Patients with diabetes mellitus or hypertension.

Outcomes

Primary Outcomes

Macular superficial capillary plexus (SCP) and deep capillary plexus (DCP

to detect degree of changes in vessel density at superficial and deep macular plexuses before and after injection of each group of anesthesia

Time frame: ntervention & data collection :4-6 monthes

Central Contacts

Amira aldesoky abdelazeem ahmed, resident

CONTACT

01055330581 amera.desouky@med.sohag.edu.eg

Mohamed Anber Abdellatif, professor

CONTACT

01009801966

Data from ClinicalTrials.gov

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