Efficacy and Safety of Pracytarabine Versus Regorafenib in the Treatment of Patients With Hepatocellular Carcinoma

Inclusion Criteria: 1. Aged 18-75 years, regardless of gender. 2. Diagnosed with HCC either by histopathological and/or cytological examination meeting pathological diagnostic criteria, or in line with the clinical diagnostic criteria of the aforementioned guidelines. 3. Unresectable or metastatic HCC, and have experienced treatment failure with targeted drugs and immune checkpoint inhibitors. 4. Child-Pugh liver function score: Class A/B (≤7 points). 5. Expected survival time ≥ 3 months. 6. ECOG performance status 0 or 1. 7. Barcelona Clinic Liver Cancer (BCLC) stage B or C. 8. No severe involvement of the portal vein, and no invasion of the hepatic vein, superior vena cava, or inferior vena cava. Exclusion Criteria: 1. Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC. 2. Previous history of liver or other organ transplantation. 3. Has participated in another clinical study within 4 weeks prior to the first dose. 4. Has a known history of, or any evidence of CNS metastases. 5. Clinically symptomatic or recurrently drained pleural effusion, pericardial effusion, or ascites. 6. History of bleeding event due to esophageal and/or gastric varices within 3 months prior to the first dose of study treatment.