Functional MRI for Monitoring Progression and Assessing Trends in ILD

University Hospital Heidelberg200 enrolled

Overview

The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives: Determine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different. Analyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs. Assess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

200

Conditions

Interstitial Lung Diseases (ILD)

Interventions

Participants will undergo a lung MRI protocol consisting of structural imaging, non-contrast functional imaging, and contrast-enhanced imaging. Some sequences are custom-developed and performed during free breathing to accommodate patients with respiratory limitations.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical indication for a routine HRCT because of either newly diagnosed idiopathic pulmonary fibrosis (IPF) or hypersensitivity pneumonitis (HP) or idiopathic non-specific interstitial pneumonia (iNSIP), suspected diagnosis, or follow-up * Capacity to consent * Ability to participate fully in the study (defined by the ability to lie still for the duration of imaging) Exclusion Criteria: * Pregnancy and breast feeding * Persons under the age of 18 and persons not able to give informed consent * Any medical conditions that could hinder the ability to adhere to the protocol * Any MRI contraindication, including previous allergic reactions to Gd-based MRI contrast material and renal dysfunction (eGFR \< 30 ml min/1,73 m2)

Locations (2)

Thoraxklink Heidelberg - Universitätsklinikum Heidelberg

Heidelberg, Germany

RECRUITING

Universitätsklinikum Schleswig-Holstein, Campus Kiel

Kiel, Germany

ACTIVE_NOT_RECRUITING

Outcomes

Primary Outcomes

Identification of ILD Subtypes Using Baseline MRI Metrics

Assess whether baseline MRI metrics can accurately differentiate subtypes of interstitial lung disease, using clinician diagnosis (based on multidisciplinary discussion) as the reference standard.

Time frame: Baseline (first MRI scan)

Secondary Outcomes

Correlation of Longitudinal MRI Changes with Disease Progression

Evaluate changes in MRI metrics over time and their correlation with ILD progression, using ATS/ERS/JRS/ALAT criteria.

Time frame: From enrollment (baseline MRI) through up to 1-year after enrollment; follow-up assessments will only be performed if clinically indicated.