The goal of this observational study is to learn about the impact of donor heart procurement time based on circadian rhythm on the long-term outcomes of heart transplant recipients. The main question it aims to answer is: Does the time of day when a donor heart is procured-specifically during the circadian repression phase (00:00-12:00) versus the activation phase (12:00-00:00)-affect post-transplant survival and rejection rates in patients with end-stage heart failure? Patients undergoing heart transplantation at the study hospital will have leftover donor heart tissue and preservation fluid collected during surgery for multi-omics analysis. These participants will then be followed prospectively for up to three years to track survival and rejection outcomes.
Study Type
OBSERVATIONAL
Enrollment
200
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
Overall survival
Post-heart-transplant survival assessed from the date of transplantation until death from any cause, evaluated through regular follow-up visits over the study period.
Time frame: From date of transplantation up to 3 years post-transplant.
Acute rejection rate
Incidence of acute cellular rejection following heart transplantation, diagnosed based on endomyocardial biopsy per International Society of Heart and Lung Transplantation (ISHLT) grading criteria (grade 2R or higher).
Time frame: From date of transplantation up to 3 years post-transplant.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.