Longitudinal Follow-up and Health-Related Outcomes in Liver Transplant Recipients and Living Donors

Second Affiliated Hospital, Zhejiang University, School of Medicine9,999 enrolled

Overview

This prospective cohort study aims to identify risk factors for postoperative adverse events in liver transplant recipients and living donors. By collecting comprehensive clinical data and conducting systematic long-term follow-up, the researchers intend to establish a specialized, standardized, and individualized follow-up management system. The ultimate goal is to optimize intervention strategies and improve patient prognosis and quality of life for both recipients and donors.

Study Type

OBSERVATIONAL

Enrollment

9,999

Conditions

Living Donor Liver Transplantation Recipients Deceased Donor Liver Transplantation Recipients Living Liver Donor

Interventions

liver transplantation

Patients undergo standard liver transplantation according to clinical protocols. Postoperative management and follow-up are conducted per routine standard of care. Clinical data, including survival, adverse events, and quality of life (assessed by questionnaires/scales), are collected observationally at regular follow-up intervals.

Living Donor HepatectomyPROCEDURE

Living donors undergo standard hepatectomy procedures. Postoperative recovery and long-term health outcomes are monitored through routine follow-up visits and assessments.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients undergoing liver transplantation or living donor hepatectomy at the study center (living donor should be approved by the hospital ethics committee for living organ donation); 2. Age 18 years or older; 3. Willing to participate in the long-term follow-up management program; 4. Signed informed consent form; Exclusion Criteria: 1. Patients undergoing combined organ transplantation 2. Patients with severe mental illness or cognitive impairment who are unable to cooperate with follow-up assessments. 3. Donors whose surgery is aborted intraoperatively for any reason. 4. Unable or unwilling to comply with the long-term follow-up schedule.

Outcomes

Primary Outcomes

Long-term Incidence of Postoperative Adverse Events

Evaluation of the cumulative incidence of postoperative complications

Time frame: From date of surgery up to 20 years

Secondary Outcomes

Overall Survival

Time frame: Up to 20 years

Graft Survival Rate

Time frame: Up to 20 years

Patient-Reported Outcome questionnaire

Assessment of multiple dimensions of patient health status, including physical functioning, mental health, social well-being, symptoms burden (e.g., pain, fatigue), and medication adherence. These domains will be evaluated using a battery of standard validated instruments

Time frame: Baseline and annually up to 20 years