Platelet Serotonin Deficiencies: the Strasbourg Experience

N/ARecruitingNCT07302087

University Hospital, Strasbourg, France50 enrolled

Overview

Hemorrhagic syndromes are investigated using algorithms established by reference centers and hemostasis societies. The investigation of platelet dense granules (nucleotide and serotonin testing) is part of the second-line tests. It can be performed in cases of platelet aggregation abnormalities in platelet-rich plasma (PRP) suggesting a secretion abnormality, or in cases where the latter is normal, it can be performed if the patient's clinical presentation points to a primary hemostasis abnormality and the clinician wishes to pursue further investigations Intraplatelet serotonin deficiencies are often iatrogenic and may be accompanied by bleeding. Their impact on platelet function is poorly documented.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hemorrhagic Syndrome

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patient (≥ 18 years old) * Treated at Strasbourg University Hospital for a hemorrhagic syndrome, suggesting a primary hemostasis abnormality and normal von Willebrand factor, during the period from January 1, 2023, to April 1, 2024. Exclusion Criteria: \- Refusal to participate in the study

Locations (1)

Centre de Ressources et de Compétences des Maladies Hémorragiques Constitutionnelles - CHU de Strasbourg - France

Outcomes

Primary Outcomes

Score of ISTH BAT Hemorrhagic Questionnaire

ISTH BAT bleeding questionnaire with its 12-item grid scored from 0 to 4: A score ≥ 4 in men or ≥ 6 in women makes the presence of a constitutional hemostasis disorder highly probable

Time frame: Up to 12 months