High-Intensity Interval or Concurrent Exercise on Oxidative Stress and Inflammation in Obese Women

University of Valladolid58 enrolled

Overview

Introduction: Menopause is associated with body composition change, an increase in the cardio-metabolic risk factor for oxidative stress. Nevertheless, it has been suggested that regular physical training is an effective non-pharmacological intervention to reduce oxidative stress and cardio-metabolic disorders in menopausal individuals. Therefore, the present study was conducted to compare the effects of twelve weeks of high-intensity interval training (HIIT) and concurrent (Conc) and on body composition, cardio-metabolic indices and oxidative stress in sedentary obese postmenopausal women. Materials and methods: Forty-five menopausal obese women voluntarily participated and were randomly assigned into three groups: a) HIIT (6-12×60s of high intensity training (85-95% HRMax) and then running for 60 seconds with low intensity (55-60% HRMax)), b) concurrent endurance (performed on training with 55-75% HRMax) and strength training (including two sets in eight exercise stations with 55-75% 1RM)) and c) control group. Training programs were done for twelve weeks, 3 times per week. Body composition, cardio-metabolic indices and oxidative stress markers were measured before and after twelve weeks of exercise training program.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Women Veterans Obese Women

Interventions

High-Intensity IntervalBEHAVIORAL

HIIT consisted of alternating high- (90-95 % HR\_max) and low-intensity (55-60 % HR\_max) aerobic bouts

concurrent trainingBEHAVIORAL

combined aerobic and resistance exercises

Control GroupBEHAVIORAL

usual daily routines

Eligibility

Sex: FEMALEMin age: 50 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women with at least 12 months of amenorrhea. * Physical abilities with the capacity to exercise safely as determined by a medical evaluation. * Women in a sedentary state, defined as performing \<150 minutes of moderate to vigorous physical activity per week during the previous year. * BMI \>25 and ≤40 kg/ m2 Exclusion Criteria: * hormone replacement therapy * smoking. * diagnosed cardiovascular, renal, or hepatic disease, uncontrolled hypertension, or any musculoskeletal limitation precluding exercise participation

Outcomes

Primary Outcomes

Concentration Malondialdehyde (MDA) (nmol/mL)

Malondialdehyde (MDA) is a highly reactive compound and a key biomarker for oxidative stress, formed primarily from the breakdown (peroxidation) of polyunsaturated fatty acids in cell membranes, indicating cellular damage