Delirium and Heart Failure

N/ANot Yet RecruitingNCT07302737

Ain Shams University100 enrolled

Overview

Biomarkers such as Systemic Immune-Inflammation Index (SII) and TG/Glucose Ratio (TyG) have shown promise in predicting delirium, reflecting the roles of inflammation and metabolic disturbances in its pathophysiology. This study aims to compare the predictive value of SII and the TyG ratio among other chemical and physiological biomarkers for diagnosing delirium and detecting its severity in older adults with heart failure. These biomarkers reflect different pathophysiological pathways implicated in delirium, including inflammation, cardiovascular stress, and metabolic dysfunction. By evaluating their individual and combined predictive abilities, this research seeks to identify potential tools for early identification of patients at high risk for delirium

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Heart Failure Delirium Confusional State

Interventions

Comprehensive Geriatric AssessmentOTHER

the Confusion Assessment Method (CAM test) or CAM-ICUOTHER

standardized tool designed to quickly and accurately diagnose delirium by assessing four key features: acute mental change, inattention, and either disorganized thinking or altered consciousness. The original CAM is used for communicative patients on general wards, relying on conversation, while the CAM-ICU is adapted for critically ill, often non-verbal patients in the ICU, using non-verbal tasks and sedation scales. By providing a rapid, reliable method for identifying this often-missed condition, both tools trigger crucial medical interventions, helping to mitigate delirium's serious risks, including longer hospital stays, long-term cognitive decline, and increased mortality.

Delirium Rating Scale - Revised-98OTHER

The Delirium Rating Scale-Revised-98 (DRS-R-98) is a standardized, expert-rated clinical tool designed specifically to measure the severity of delirium and help distinguish it from other psychiatric disorders, such as dementia, depression, and schizophrenia. Unlike the CAM/CAM-ICU, which provides a simple "yes/no" diagnosis, the DRS-R-98 quantifies how severe a patient's delirium is at a given point in time and tracks changes in that severity over the course of the illness

Eligibility

Sex: ALLMin age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Heart failure stage C Exclusion Criteria: 1. cognitive impairment 2. Major Neurological Conditions: (e.g., stroke, traumatic brain injury). 3. Hematological diseases that affect platelet, neutrophil, and lymphocyte counts. 4. Cardiogenic Shock 5. Sepsis 6. Ongoing Treatment with Immunosuppressants, or corticosteroids

Outcomes

Primary Outcomes

the sensitivity and specificity of different biomarkers of delirium in heart failure older patient

assess sensitivity and specificity of the systemic inflammatory index (SII), Rate Pressure Product (RPP), and TG/glucose ratio in predicting delirium

Time frame: Within 24 hours of hospital admission

Secondary Outcomes

in hospital morbidity

follow up cohort for possible complications like acute kidney injury, infections, or adverse drug events

Time frame: From enrollment to the hospital discharge about 6 weeks

In hospital mortality

cohort follow up throughout hospital course and mortality recorded

Time frame: From enrollment to hospital discharge about 6 weeks