Distribution and Analysis of Metastatic Lymph Nodes in Colorectal Cancer Patients (DIAMOND)

N/ANot Yet RecruitingNCT07306390

Cancer Institute and Hospital, Chinese Academy of Medical Sciences1,200 enrolled

Overview

The goal of this observational study is to learn about the spatial distribution and significance of metastatic lymph nodes in colorectal cancer patients. The main question it aims to answer is: * What is the spatial distribution pattern of metastatic lymph nodes in patients with colorectal cancer? * Can the spatial distribution pattern of metastatic lymph nodes in patients with colorectal cancer guide clinical practice? Participants should undergo regular follow-up examinations for at least 5 years after the surgery.

Study Type

OBSERVATIONAL

Enrollment

1,200

Conditions

Colon Cancer Rectal Cancer

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged between 18 and 80 years * Pathologically confirmed adenocarcinoma of the colon or rectum * Underwent radical resection for colorectal cancer with a D3 lymphadenectomy and lymph nodes were submitted for pathological examination according to standardized station-based and distance-based protocol * No distant metastasis or distant metastasis within 6 months after surgery * No history of other malignant tumors or severe systemic diseases * No immune diseases or inflammatory bowel diseases * Non-emergency surgery * With complete clinicopathological and follow-up data Exclusion Criteria: * Pathologically confirmed benign tumors or non-adenocarcinoma malignancies * Underwent local excision or palliative resection * Regional lymph nodes were not dissected or submitted for pathological examination according to the unified station-based or distance-based protocol * With distant metastasis or distant metastasis within 6 months after surgery * Dual or multiple primary colorectal cancers or concurrent other malignant tumors * Had a previous diagnosis of immune diseases or inflammatory bowel disease such as ulcerative colitis or Crohn's disease * Underwent emergency surgery * Had incomplete clinicopathological or follow-up data

Outcomes

Primary Outcomes

The spatial distribution of metastatic lymph nodes

Time frame: From enrollment to 14 days after surgery (at the completion of postoperative pathological examination)

Secondary Outcomes

Disease-free survival

Time frame: From date of surgery until the date of first documented local recurrence, distant metastasis, or date of death from any cause, whichever came first, assessed up to 60 months

Overall survival

Time frame: From date of surgery until the date of death from any cause, whichever came first, assessed up to 60 months