The study will examine the autonomic, physiologic and neurophysiologic effects of implanted Vagus Nerve Stimulation (VNS) in treatment-resistant depression patients.
The purpose of this study is to examine the autonomic and physiologic effects of implanted VNS in treatment-resistant depression patients. To examine the neurophysiologic effects of Vagus Nerve Stimulation (VNS) in treatment-resistant depression.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
12
Participants receiving vagus nerve stimulation through an implanted Vagus Nerve Stimulation Device.
Gamma and theta band phase-amplitude coupling
Measurement of EEG and ECG to quantify changes in phase-amplitude coupling in the gamma and theta band related to chronic VNS
Time frame: Baseline, Week 6 and Week 19
Resting state functional connectivity between the left dorsolateral prefrontal cortex and subgenual anterior cingulate cortex
Measurement of changes in resting state functional connectivity between the left dorsolateral prefrontal cortex and subgenual anterior cingulate cortex with chronic VNS using fMRI.
Time frame: Baseline, Week 6 and Week 19
Heart brain coupling
Measurement of heart brain coupling (heart rate entrainment in response to trains of intermittent theta burst stimulation) with VNS via an EKG sweep
Time frame: Week 19
Heart rate
Measure heart rate and heart rate variability with VNS
Time frame: Baseline, Week 6 and Week 19
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