Reports from the Kenya Red Cross Society (KRCS) in Kwale County, southern Kenya, indicate a limited impact of Ready-to-Use Therapeutic Foods (RUTFs) on malnutrition or anemia. The current RUTF formulation may have an excessively high iron content. In severely acutely malnourished (SAM) children, iron cannot be properly absorbed, leading to life-threatening diarrhea. The overall aim of this project is to develop an improved RUTF treatment that addresses acute malnutrition and anemia in children, ensuring both safety and efficacy. Specifically, to assess the impact of malnutrition on fractional iron absorption (FIA) from RUTFs in children, by comparing healthy children to those with acute malnutrition and by tracking changes in FIA in malnourished children over the course of treatment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
68
RUFT with 57Fe
Daily RUTF intake
RUFT with 57Fe
RUFT with 57Fe
RUFT with 57Fe
ETH/Oxford/JKUAT research facility
Msambweni, Kwale County, Kenya
RECRUITINGETH Zurich, Laboratory of Clinical Biopharmacy, Zurich, 8092
Zurich, Switzerland
NOT_YET_RECRUITINGFractional Iron Absorption
Time frame: Day 0
Fractional Iron Absorption
Time frame: Day 20
Fractional Iron Absorption
Time frame: Day 40
Fractional Iron Absorption
Time frame: Day 60
Hemoglobin
Iron status parameter
Time frame: Day 0
Hemoglobin
Iron status parameter
Time frame: Day 20
Hemoglobin
Iron status parameter
Time frame: Day 40
Hemoglobin
Iron status parameter
Time frame: Day 60
Hemoglobin
Iron status parameter
Time frame: Day 80
Serum ferritin
Iron status parameter
Time frame: Day 0
Serum Ferritin
Iron status parameter
Time frame: Day 20
Serum Ferritin
Iron status parameter
Time frame: Day 40
Serum Ferritin
Iron status parameter
Time frame: Day 60
soluble transferrin receptor
Iron status parameter
Time frame: Day 0
soluble transferrin receptor
Iron status parameter
Time frame: Day 20
soluble transferrin receptor
Iron status parameter
Time frame: Day 40
soluble transferrin receptor
Iron status parameter
Time frame: Day 60
C-reactive protein
inflammation status parameter
Time frame: Day 0
C-reactive protein
inflammation status parameter
Time frame: Day 20
C-reactive protein
inflammation status parameter
Time frame: Day 40
C-reactive protein
inflammation status parameter
Time frame: Day 60
α₁-acid glycoprotein
inflammation status parameter
Time frame: Day 0
α₁-acid glycoprotein
inflammation status parameter
Time frame: Day 20
α₁-acid glycoprotein
inflammation status parameter
Time frame: Day 40
α₁-acid glycoprotein
inflammation status parameter
Time frame: Day 60
body weight
Time frame: Day 0
body weight
Time frame: Day 20
body weight
Time frame: Day 40
body weight
Time frame: Day 60
body height
Time frame: Day 0
body height
Time frame: Day 20
body height
Time frame: Day 40
body height
Time frame: Day 60
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