Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis

Inclusion Criteria: \- Diagnosed with stage II periodontitis based on AAP/EFP 2018 classification • Minimum of two non-adjacent periodontal pockets \<5 mm in different quadrants • Systemically healthy individuals willing to participate and comply with follow-up visits • Radiographic bone loss (ranged from is 10-20% mostly horizontal Exclusion Criteria: History of systemic diseases affecting periodontium (e.g., diabetes, osteoporosis) • Use of antibiotics, anti-inflammatories, or antioxidant supplements in the past 3 months • Smoking or tobacco use • Pregnancy or lactation • Allergy to melatonin or related compounds \-