The aim of this work is to assess the benefit of coenzyme Q10 supplementation, in addition to standard antibiotic and other supportive therapy, in the management of hospitalized children with community acquired pneumonia
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
120
60 children with community acquired pneumonia will receive oral coenzymeQ10 in capsule form at a dose of 100-200 mg/kg/day, as adjunct therapy to the usual pneumonia treatment till the recovery of the disease.
Tanta University
Tanta, Gharbia Governorate, Egypt
Normalization of respiratory rate
Time frame: 3 days
Normalization of temperature
Time frame: 3 days
Normalization of oxygen saturation
Time frame: 3 days
Normalization of Feeding Behavior Assessed by Oral Intake Tolerance
Normalization of feeding refusal will be assessed by evaluating the child's ability to tolerate age-appropriate oral feeding without refusal over a 3-day observation period.
Time frame: 3 days
Serum C-Reactive Protein (CRP) Level
Blood samples will be collected, and CRP concentration will be expressed in milligrams per liter (mg/L).
Time frame: 5 days
Serum Lactate Dehydrogenase (LDH) Level
LDH concentration will be reported in units per liter (U/L) from venous blood samples.
Time frame: 5 days
Prognostic Nutritional Index
Time frame: 5 days
Systemic Immune-Inflammation Index
Time frame: 5 days
Serum C-Reactive Protein to Albumin Ratio (CRP/Albumin Ratio)
The serum C-reactive protein to albumin ratio (CRP/albumin ratio) will be calculated as a single composite outcome measure using laboratory values obtained from the same blood sample.
Time frame: 5 days
Time of clinical stability
Time frame: 3-5 days
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Length of hospital stay
Time frame: 10-21 days
Number of Participants Requiring Surgical Intervention
This outcome measures whether a participant undergoes any surgical intervention related to the study condition during the follow-up period. Surgical intervention is defined as any operative procedure performed under general or regional anesthesia, as documented in the medical record. The outcome will be recorded as a binary variable (Yes/No) for each participant and summarized as the number and proportion of participants requiring surgical intervention.
Time frame: 21-30 days