The Use of Rhythmic Light Therapy in Mild Cognitive Impairment

Icahn School of Medicine at Mount Sinai20 enrolled

Overview

In this within-subjects, crossover study, participants will undergo Electroencephalogram (EEG) recordings before, during, and after each of three 1-hour sessions. All participants will experience all three conditions: (1) dual-frequency visual (10 and 40 Hz), (2) single-frequency visual (40 Hz), and (3) non-rhythmic stimulation. EEG spectral power and amplitude coupling will be analyzed to determine whether stimulation-induced increases in alpha-gamma neural synchrony translate to improvements in cognitive performance.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Mild Cognitive Impairment

Interventions

Flickering LightDEVICE

Red Flickering Light programed to three different visual stimulations

Eligibility

Sex: ALLMin age: 55 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * History of Mild Cognitive Impairment with a Montreal Cognitive Assessment score between 18 and 25 Exclusion Criteria: * History of epilepsy or photosensitivity * Blindness or other obstructive vision conditions * retinal diseases * presence of another brain disease accounting for their cognitive status

Locations (1)

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Outcomes

Primary Outcomes

EEG-based neural synchrony

Change in spectral power and amplitude in the alpha and gamma EEG bands. Increase in power and amplitude is indicative of increases in neural synchrony.

Time frame: 5 minute EEG recording will be done at start, middle and end of each one-hour session, each session separated by one week

Secondary Outcomes

Digit Span Task

Change in cognition will be measured by the Digit Span Task which is a working memory task. Increase in accuracy and response time indicates improved cognitive performance. Digit Span. Memory span is the longest list of items that a person can repeat back in correct order immediately after presentation on 50% of all trials. Items may include words, numbers, or letters. The task is known as digit span when numbers are used. Memory span is a common measure of short-term memory. A digit-span task is used to measure working memory's number storage capacity. The item score is the sum of the scores on the two trials for that item (range=0-2). The total raw score for backwards digit span is the sum of the item scores; maximum backwards digit span total raw score is 16 points. Higher score indicates better health outcomes.

Time frame: Completed at start and end of each one-hour session, each session will be separated by one week

Data from ClinicalTrials.gov

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