Ozonated Gel and Titanium Platelet-rich Fibrin (on Palatal Wound Healing

N/ACompletedNCT07320391

Alexandria University39 enrolled

Overview

Background: autogenous soft tissue grafts can be considered the gold standard for treatment of mucogingival problems. The most common site for harvesting the graft is the palate. The palatal donor site for free gingival graft (FGG) significantly influences the pain and discomfort experienced by the patient, and there is a potential for postoperative bleeding.To overcome these problems many dressing materials associated with topical formulae have been used. Aim: The objective of this study is to assess the effect of topically applied ozonated oil on palatal wound healing and compare it to the effect of titanium platelet rich fibrin (TPRF)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Palatal Lesion

Interventions

After harvesting the free palatal grafts, an adrenaline-soaked sterile surgical gauze was applied to the palatal donor sites with firm pressure for 5 minutes to achieve hemostasis. Subsequently, ozonated gel loaded on gelatin foam was placed over the donor sites and stabilized using flowable composite.

T-PRF ApplicationOTHER

Twenty milliliters of venous blood were collected from the antecubital vein and immediately centrifuged at 2800 rpm for 12 minutes. The resulting T-PRF clots were retrieved using sterile tweezers, separated from the red blood cell layer, and placed on sterile woven gauze. The clots were allowed to exude serum for 20 minutes, then gently compressed between gauze to form T-PRF membranes. The membranes were trimmed to fit the FGG donor site and covered with flowable composite.

Conventional treatmentOTHER

After harvesting the free palatal grafts, an adrenaline-soaked sterile surgical gauze was applied to the palatal wounds with firm pressure for 5 minutes to achieve hemostasis. The palatal wounds were then covered with flowable composite.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Isolated gingival recession defects on the mandibular and maxillary anterior teeth with insufficient keratinized gingiva. * Good oral hygiene Exclusion Criteria: * Patients reporting systemic conditions that may compromise healing or bone metabolism * Patients having a history of radiotherapy, chemotherapy or bisphosphonate therapy. * Pregnant women or those planning to get pregnant during the study course * History of periodontal disease or previous periodontal surgery on the experimental sites * Smoking or any other deleterious habits.

Outcomes

Primary Outcomes

Change in pain scores

Patients will be asked to grade the severity of pain using VAS. It ranges across a continuum from none to an extreme amount of pain in a straight horizontal 10 cm line \[from 0-100 mm\].

Time frame: Up to 14 days

Change in wound area

Standardized clinical photographs of the palatal surgical sites will be obtained on the day of surgery and at 3, 7, 10, and 14 days postoperatively. Photographs will be taken perpendicular to the wound area, with a standard-sized visual scale placed adjacent to the palatal wounds to allow accurate wound size measurement and analysis.

Time frame: Baseline, 3 days, 7 days, 10 days, and 14 days