Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium by Frailty Status in Older Surgical Patients

Chinese PLA General Hospital6,475 enrolled

Overview

Both frailty and a reduced preoperative lymphocyte-to-monocyte ratio (LMR) are known risk factors for postoperative delirium (POD). However, whether the relationship between LMR and POD varies by frailty status remains unclear. This study aimed to evaluate the frailty-stratified association between preoperative LMR and POD in older surgical patients.

Study Type

OBSERVATIONAL

Enrollment

6,475

Conditions

Postoperative Delirium (POD)Frailty at Older Adults Lymphocyte

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged ≥65 years; * Underwent elective noncardiac, nonneurosurgical procedures; * Completed the preoperative health and functional status questionnaire. Exclusion Criteria: * Severe dementia, language disorders, significant hearing or visual impairments, or coma; * Cognitive function below the Mini-Mental State Examination thresholds (\<18 for illiterate individuals, \<21 for individuals with primary education, and \<25 for individuals with secondary education or higher); * Surgery performed under local anesthesia or monitored anesthesia care; * Missing lymphocyte or monocyte count data; * Missing postoperative delirium assessment; * Incomplete preoperative FRAIL scale evaluation; * Missing data for more than 20% of covariates.

Locations (1)

28 Fuxing Road, Haidian District

Beijing, China

Outcomes

Primary Outcomes

The primary outcome was the occurrence of postoperative delirium (POD).

The primary outcome was the occurrence of POD, evaluated by trained researchers using the 3-Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM).

Time frame: POD assessment was performed twice daily for up to seven consecutive postoperative days or until hospital discharge, whichever occurred first.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.