Retrospective Evaluation of the Long-term Effectiveness of the CR500™ SINGLE-DOSE GEL Medical Device in Patients With Knee Osteoarthritis (KOA)

Need for additional therapies before and after CR500™.

To collect information, via a questionnaire, on the need for joint injections before and after CR500™ therapy. Did the patients receive HA infiltration before the therapy with CR500? Yes No Had the patients received another treatment for the same pathology after CR500™? Yes No

Time frame: At least after 24 Months from the end of NCT05661162 study visit.

Timing and type of other interventions performed on the same knee with KOA treated with CR500™ in the NCT05661162 study.

To collect, via a questionnaire, information on the timing and type of other interventions performed on the same KOA-affected knee treated with CR500™ in the NCT05661162 study, as follows: After the treatment with CR500 have you undergone any other therapies for the treatment of OA? Yes No If yes, which ones? Infiltrative Therapies (HA, PRP, or corticosteroids) Oral anti-inflammatory or pain-relief therapies Topical anti-inflammatory or pain-relief therapies Electromedical therapies Physiotherapy Do you roughly remember when (month/year)?

Time frame: At least after 24 Months from the end of NCT05661162 study visit

Long-term satisfaction with the CR500™ treatment.

To collect, via a questionnaire, information on long-term patient satisfaction at least 24 months after the last application of CR500™. Would you repeat the treatment with CR500™? Yes No Uncertain