Postoperative Frailty Trajectories and One-Year Mortality in Older Surgical Patients

Chinese PLA General Hospital4,417 enrolled

Overview

Frailty is a key predictor of adverse outcomes in older surgical patients, yet its longitudinal evolution and potentially reversible nature remain underexplored in perioperative settings. This study aimed to characterize postoperative frailty trajectories in older patients and to examine their association with one-year mortality, as well as factors influencing trajectory group.

Study Type

OBSERVATIONAL

Enrollment

4,417

Conditions

Frailty in Older Adults All Cause Mortality Trajectory

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged ≥65 years; * Underwent elective non-cardiac, non-neurosurgical procedures; * Completed standardized frailty assessments both preoperatively and postoperatively. Exclusion Criteria: * Severe dementia, language disorders, significant hearing or visual impairments, or coma; * Cognitive function below the Mini-Mental State Examination (MMSE) thresholds (\<18 for illiterate individuals, \<21 for individuals with primary education, and \<25 for individuals with secondary education or higher); * Surgery performed under local anesthesia or monitored anesthesia care; * Surgical duration ≤30 minutes; * Missing data on postoperative complications or one-year mortality required for this study; * Incomplete frailty assessments at 1, 3, and 6 months after surgery.

Locations (1)

28 Fuxing Road, Haidian District

Beijin, Beijing Municipality, China

Outcomes

Primary Outcomes

The primary outcome was one-year all-cause mortality.

The primary outcome was one-year all-cause mortality, determined through structured telephone follow-up.

Time frame: At the one-year postoperative follow-up.

Data from ClinicalTrials.gov

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