The purpose of this study is to assess the safety and tolerability of BMS-986525 alone and in combination with Pumitamig in participants with Relapsed/Refractory Small Cell Lung Cancer
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
240
Specified dose on specified days
Specified dose on specified days
Karmanos Cancer Institute
Detroit, Michigan, United States
RECRUITINGRoswell Park Cancer Institute
Buffalo, New York, United States
Number of participants with adverse events (AEs)
Time frame: Up to approximately 2 years
Number of participants with serious adverse events (SAEs)
Time frame: Up to approximately 2 years
Number of participants with AEs meeting dose-limiting toxicity (DLT) criteria
Time frame: Up to 21 days
Number of participants with AEs leading to discontinuation
Time frame: Up to approximately 2 years
Number of participants with AEs leading to death
Time frame: Up to approximately 2 years
Objective response rate (ORR) per Response Evaluation Criteria in Solid Tumor Version 1.1 (RECIST v1.1) by investigator assessment
Time frame: Up to approximately 3 years
Maximum observed concentration within a dosing interval (Cmax)
Time frame: Up to approximately 2 years
Time of maximum observed plasma concentration within a dosing interval (Tmax)
Time frame: Up to approximately 2 years
Area under the concentration-time curve within a dosing interval (AUC(TAU))
Time frame: Up to approximately 2 years
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Duke Cancer Institute
Durham, North Carolina, United States
RECRUITINGUniversity Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
RECRUITINGSCRI Oncology Partners
Nashville, Tennessee, United States
RECRUITINGLocal Institution - 0029
Beijing, Beijing Municipality, China
NOT_YET_RECRUITINGShanghai East Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGIstituto Clinico Humanitas
Rozzano, Milano, Italy
RECRUITINGLocal Institution - 0020
Hirakata, Osaka, Japan
NOT_YET_RECRUITINGLocal Institution - 0018
Chuo-ku, Tokyo, Japan
NOT_YET_RECRUITING...and 3 more locations