The Study of ENB With Ultra-thin Cryobiopsy in the Diagnosis of Peripheral Pulmonary Nodules

Inclusion Criteria: 1. age 18 to 90 years; 2. pulmonary nodules detected by chest CT, suspected malignant nodules or unknown cause should be confirmed by biopsy; 3. chest CT showed that the nodule was located in the segmental bronchus and below, and the maximum diameter of the nodule was 8 mm to 30 mm.It was not accessible by conventional bronchoscopy; 4. if chest CT showed multiple pulmonary nodules, one of the pulmonary nodules was selected as the target lesion. Exclusion Criteria: 1. contraindications to the bronchoscopy procedure; 2. high risk of bleeding, such as bronchial artery penetration or suspected lung metastasis of renal cell carcinoma; 3. electromagnetic source implanted in the body; 4. contraindications to anesthesia; 5. pregnant woman; 6. participated in other studies within three months and did not withdraw or finish, affect the observation of this study; 7. inability or unwillingness to provide informed consent or comply with the follow-up schedule.