Evaluation of Pain Relief and Bacterial Reduction After Using Calcium Hydroxide With Mesoporous Silica Nanoparticles as an Intracanal Medicament in Necrotic Mandibular Molars: A Randomized Controlled Clinical Trial

N/AActive Not RecruitingNCT07327996

Future University in Egypt42 enrolled

Overview

This study compares how well different root canal medications reduce pain and bacteria after treatment of lower molar teeth with necrotic pulp. It tests whether adding mesoporous silica nanoparticles-antibacterial particles-to calcium hydroxide makes the treatment more effective. Forty-two adult patients will be randomly assigned to receive either calcium hydroxide alone, nanoparticles alone, or a mix of both for one week during root canal therapy. measure patients' pain levels after 6h,12h,24,48h and 72 hours from treatment and the number of bacteria before and after treatment to see which method gives the best results. The goal is to make root canal treatments more comfortable and successful for future patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Necrotic Pulp

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

* Inclusion Criteria: 1. Patients with an age range between 18 to 40. 2. No sex predilection. 3. Patients with necrotic pulp. 4. Patients able to sign informed consent. 5. Restorable teeth. 6. Positive patient's acceptance for participating in the study. 7. Type III distal and mesial canal of first mandibular molar. * Exclusion Criteria: 1. Pregnant females 2. Medically compromised patients. 3. Patients having analgesics before the treatment 4. If antibiotics have been administrated during the past two weeks pre-operatively. 5. Patients having bruxism or clenching 6. Patients having sever malocclusion associated with traumatic occlusion. 7. Teeth that have: 1. Peri-apical radiolucency 2. Root resorption. 3. Pulp stones or calcifications. 4. Previous endodontic treatment.

Outcomes

Primary Outcomes

Post-operative pain after application of different intracanal medications

measuring Post-operative pain by Numerical rate scale and pain level will be assigned to one of 4 categorical score: none(0) - mild(1-3), severe(7-10) after 6h,12h,24,48h

Time frame: from 6 to 72 hours from the treatment

Secondary Outcomes

bacterial load change after intracanal medication

Recording the percentage of bacterial load reduction by collecting samples by paper points, first sample after access cavity and before RCT, second sample after mechanical instrumentation, third sample after removing intracanal medication from the canal

Time frame: immediately in the intervention and after 1 week