The goal of this observational study is to determine the prevalence of remission among adults with severe asthma, as well as the factors associated with remission in Thailand. The main question the study aims to answer is: What is the prevalence of remission among adults with severe asthma in Thailand? Participants will complete questionnaires on asthma symptoms and undergo pulmonary function testing and a blood test once.
This study is a cross-sectional study. Thai patients aged 18 years or older with severe asthma are included in the study. Participants will complete two questionnaires about asthma control: the Global Initiative for Asthma (GINA) and the Asthma Control Test (ACT), and will perform spirometry, a fractional exhaled nitric oxide (FeNO) test, and blood eosinophil counts (BEC).
Study Type
OBSERVATIONAL
Enrollment
230
GINA and ACT are questionnaires used to assess the level of asthma control.
Spirometry is a tool used to assess pulmonary function.
FeNO is a tool used to assess eosinophilic airway inflammation and asthma remission.
Prevalence rate of severe asthma remission
Prevalence rate of remission in adults with severe asthma
Time frame: The beginning of the study
Association of clinical characteristics with severe asthma remission
The association between severe asthma remission and the following variables will be evaluated: 1. Asthma symptom control; Asthma Control Test (ACT) score (range 5-25) 2. Exacerbation history; Number of asthma exacerbations requiring systemic corticosteroids in the previous 12 months 3. Oral corticosteroid use; Daily oral corticosteroid use (yes/no) and cumulative dose (mg/year) 4. Asthma duration; Years since asthma diagnosis
Time frame: The beginning of the study
Association of lung function with severe asthma remission
The association between severe asthma remission (binary outcome: remission vs. non-remission) and pulmonary function assessed using spirometry (FEV1 % predicted and FEV1/FVC ratio).
Time frame: The beginning of the study
Association of inflammatory biomarkers with severe asthma remission
The association between severe asthma remission (binary outcome: remission vs. non-remission) and inflammatory biomarkers assessed using blood eosinophil count (cells/µL) and fractional exhaled nitric oxide (FeNO) (parts per billion, ppb).
Time frame: The beginning of the study
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BEC is a tool used to assess eosinophilic inflammation and asthma remission.