Efficacy and Safety of Coenzyme I for Injection on Vascular Aging.

Inclusion Criteria: 1. Ages 40-70 years; 2. cf-PWV was abnormally elevated and above the upper limit of its age-and blood-pressure matched reference range; 3. Systolic Blood Pressure \< 160 mmHg and ≥ 140 mmHg or Diastolic BP \< 100 mmHg ≥ 90mmHg; 4. Signed informed consent. Exclusion Criteria: 1. Consumption of foods or medications containing high levels of NAD+, NR, NAM, NMN, or niacin-related components (including Vitamin B3 and natural health products) within 3 months prior to screening； 2. History of major cardiovascular or cerebrovascular events, including myocardial infarction, angina, stroke, or hospitalization for arterial revascularization； 3. Systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg； 4. Diagnosis of malignant tumor； 5. Known allergy or history of severe adverse reactions to Coenzyme I injection or any of its components； 6. History of severe allergies or infusion reactions； 7. Women who are pregnant, breastfeeding, or planning pregnancy； 8. Severe hepatic or renal dysfunction: ALT or AST \> 5 times the upper limit of normal; glomerular filtration rate ≤ 30 mL/min/1.73 m²； 9. Concurrent participation in another clinical trial without completion of the follow-up period； 10. Other conditions deemed by the investigator as unsuitable for inclusion, such as psychiatric or psychological disorders.