Analysis of the Role of IgE Proteoforms in Health and Disease

KU Leuven200 enrolled

Overview

The goal of this observational study is to evaluate the role of IgE proteoforms in healthy volunteers and in patients with type I allergy, patients with chronic spontaneous urticaria, patients with a recent history of anaphylaxis, patients with mastocytosis, patients with hereditary alpha tryptasemia, patients with X-linked agammaglobulinemia (XLA), and patients undergoing desensitization for venom or medication allergy.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Anaphylaxis Mastocytosis X-linked Agammaglobulinaemia Venom Allergy Chronic Spontaneous Urticaria (CSU)Type I Allergy Medication Allergy Healthy Control

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * CSU and type I allergic diseases (including anaphylaxis and desensitization), atopic dermatitis, mastocytosis, XLA and HaT (informed consent, age: any available adult subject, gender: any available subject, clinical phenotype and specific information about the allergy (e.g. severity, medication, medical history, laboratory testing) * Healthy controls (informed consent, age matched to the allergic patients, gender matched to the allergic patients, patient-reported symptoms related to allergy to aeroallergens, food, drugs, hymenoptera venom, CSU) Exclusion Criteria: * Absence of informed consent * Age \< 18 years old

Data from ClinicalTrials.gov

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Analysis of the Role of IgE Proteoforms in Health and Disease

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes