ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF

Inclusion Criteria: * Adult patient, age ≥18 years * Expressed consent to the inclusion * Patient hospitalized on ICU with ALF or ACLF diagnosis * Recently meeting the inclusion to liver transplantation * Present on a waiting list to liver transplant * Unsuitable for inclusion to liver transplantation - indicated for support therapy only, but not indented to palliative care Exclusion Criteria: * Disagreement with the study * Infaust prognosis with expected survival less than 24 hours * Physiologically/biologically very advanced stage patients condition, severe lung disease (Gold criteria 3 or 4), heart failure (functional class NYHA III or IV) or neurological disease, as well as ACLF-3. * Advanced oncological disease (expected life expectancy below 6 months) * Severe degree of Frailty syndrome in secondary severe sarcopenia (muscle and malnutrition) or reduced performance state according