Corneal stromal injection is an emerging local drug delivery method, characterized by strong targeting, high drug concentration, and prolonged duration of action. It has been preliminarily applied in the treatment of fungal keratitis and neurotrophic corneal diseases. This study aims to investigate the safety and efficacy of anti-VEGF drugs delivered via corneal stromal injection in neovascularization caused by HSK (Herpes Simplex Keratitis). The study has clear medical significance and technical feasibility, and it is expected to promote innovation in the treatment paradigm for corneal neovascularization.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
The experimental group received intrastromal corneal injections of anti-VEGF (Vascular Endothelial Growth Factor) medication in conjunction with antiviral medication therapy
The control group was treated with conventional antiviral topical ocular drops.
1 Xihu Avenue, Shangcheng District,Hangzhou, Zhejiang,China,Hangzhou, Zhejiang Completed
Hangzhou, Zhejiang, China
RECRUITINGChange in Neovascularization Area
Time frame: 1、2、4、8、12 week
Corneal Clarity Score
Time frame: 1、2、4、8、12 week
Best Corrected Visual Acuity (BCVA)
Time frame: 1、2、4、8、12 week
Conjunctival Hyperemia Score
Time frame: 1、2、4、8、12 week
Corneal Endothelial Cell Count
Time frame: 1、2、4、8、12 week
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