The goal of this clinical trial is to see if a nurse-led program (early movement, leg-sleeve squeezes, and blood tests) can prevent dangerous leg blood clots in adults who have just had brain or spine surgery. Main questions it aims to answer: * Does the program lower the number of clots within 30 days after surgery? * Is the program safer and more accurate than the usual clot-risk score nurses already use? Researchers will compare patients who receive the nurse-led program with patients who receive standard hospital care. Participants will: * Be randomly assigned to one of the two groups. * Have regular leg ultrasounds to check for clots. * Wear a small activity tracker if they are in the nurse-led group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
1,286
Graded early-movement plan starting within 24 h of surgery * Unconscious patients: passive leg exercises 10-15 min, 3× daily * Conscious patients: assisted leg, sitting and walking sessions escalated daily (target ≥ 40 min total activity, logged automatically by a wrist-band activity tracker) Intermittent pneumatic compression (IPC) * 2 h/session, 2× daily, 30-45 mmHg while in bed, continued until independent walking D-dimer blood checks on post-op days 1, 3, 7 and 14; any rise ≥ 20 % or level \> 2 mg/L triggers an extra leg ultrasound Continuous safety watch (heart rate, blood pressure, intracranial pressure if monitored); IPC or movement is paused if pressure \> 20 mmHg or vital signs become unstable
West China Hospital of Sichuan University
Chengdu, Sichuan, China
Incidence of objectively confirmed lower-extremity deep-vein thrombosis (DVT)
diagnosed by blinded duplex ultrasound using standard non-compressibility or intraluminal thrombus criteria.
Time frame: 30 days
Time from surgery to first objectively confirmed DVT (days)
Time from surgery to first objectively confirmed DVT (days)
Time frame: 30 days
All-cause mortality within 30 days
All-cause mortality within 30 days
Time frame: 30 days
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