This clinical trial compares a physical activity program to a health education program for improving memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer. Compared to non-Hispanic White breast cancer survivors (BCS), Hispanic BCS report greater depressive symptoms, emotional distress, anxiety, fear of recurrence, pain, fatigue, and financial toxicity, in addition to more cancer-related psychosocial needs and lower quality of life and social well-being. Cancer-associated cognitive decline (CACD) is a related symptom that has gained increasing attention in clinical research. Based on disparities in other outcomes, it is likely that Hispanic BCS also experience greater CACD than non-Hispanic White BCS, but interventions targeting CACD in Hispanic BCS are non-existent and critically needed. The benefits of aerobic exercise among BCS are well documented and include improvement in health outcomes that are associated with cognitive function including fatigue, anxiety, depression, and sleep. A physical activity program that includes aerobic exercise may be more effective than simple health education for improving cognitive functions like memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
10
Ancillary studies
Participate in walking program
Ancillary studies
Undergo fMRI
Ancillary studies
Receive health education
Ancillary studies
Ancillary studies
Ancillary studies
Ancillary studies
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Change in inhibitory control
Change in interference score on Stroop task, with positive values indicating greater inhibitory control
Time frame: Baseline to post-intervention (month 6)
Change in cognitive flexibility
Change in accuracy on Shifting Attention task, with higher values indicating greater cognitive flexibility
Time frame: Baseline to post-intervention (month 6)
Change in executive function processing
Change in reaction time on Shifting Attention task, with lower values indicating greater cognitive flexibility
Time frame: Baseline to post-intervention (month 6)
Change in short-term memory
Change in accuracy on Visual Memory task, with higher accuracy indicating greater short-term memory
Time frame: Baseline to post-intervention (month 6)
Change in verbal memory
Change in number recalled on Hopkins Verbal Learning task, with higher values indicating greater verbal memory
Time frame: Baseline to post-intervention (month 6)
Change in working memory
Change in reaction time the 4-part Continuous Performance task, with lower values indicating greater working memory
Time frame: Baseline to post-intervention (month 6)
Change in processing speed
Change in reaction time on Symbol Digit Coding task, with lower values indicating greater processing speed
Time frame: Baseline to post-intervention (month 6)
Change in attention
Change in choice reaction time on Continuous Performance task, with lower values indicating greater sustained attention
Time frame: Baseline to post-intervention (month 6)
Change in brain volume
Change in mean cortical thickness of brain regions of interest as measured by an anatomic MRI brain scan
Time frame: Baseline to post-intervention (month 6)
Change in white matter integrity
Change in fractional anisotropy as measured by diffusion MRI.
Time frame: Baseline to post-intervention (month 6)
Change in resting state functional connectivity
Change in within-network pairwise correlation estimates as measured using a multiband echo planar imaging (mb-EPI) functional MRI sequence
Time frame: Baseline to post-intervention (month 6)
Change in self-reported cognitive function - FACT-Cog
The perceived cognitive impairments subscale of the Functional Assessment in Cancer Therapy - Cognition (FACT-Cog) will be used to measure self-reported cognition. Scores range from 0-72, with higher scores indicating better cognitive function.
Time frame: Baseline to post-intervention (month 6)
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