Oral leukoplakia (OL) is recognized as the most common potentially malignant disorder of the oral mucosa. The pathogenesis of OL is complex and multifactorial, with oxidative stress playing a central role. Topical antioxidants have gained attention as therapeutic options to help stabilize lesions and potentially prevent malignant transformation. Both CoQ10 and curcumin have demonstrated a clinical success as strong antioxidants showing their capacity to reduce the lesion size and to stabilize the disease, ultimately preventing progression into oral malignancy. Aim: This study aims to clinically and biochemically assess the effectiveness of topical Coenzyme Q10 and Curcumin in the management of homogeneous oral leukoplakia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
34
Application will be performed 2-3 times daily for 4 weeks.
Application will be performed 2-3 times daily for 4 weeks.
Outpatient Clinic of Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt
Alexandria, Egypt
RECRUITINGChange in lesion size
measured clinically with a periodontal probe and/or digital images
Time frame: baseline, 4 weeks, and 12 weeks
Change in salivary markers
Unstimulated whole saliva will be collected to assess salivary oxidative stress
Time frame: baseline, 4 weeks, and 12 weeks
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