This is a Phase 2, open-label, multi-center clinical study to evaluate the safety and tolerability of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung disease (PH-ILD) on a background inhaled treprostinil.
This study is an open-label study with an extension. The study consists of 2 periods: an open label treatment period (16 weeks) and an extension (beyond 16 weeks). Participants will receive mosliciguat in the 16-week treatment period. All participants who complete the 16-week treatment period may continue to participate in the extension period where all participants will receive mosliciguat.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Dose level 1, 2, or 3 for inhalation
Dry powder inhaler for mosliciguat delivery
Clinical Research Site
Santa Barbara, California, United States
RECRUITINGClinical Research Site
Torrance, California, United States
RECRUITINGClinical Research Site
Kissimmee, Florida, United States
RECRUITINGClinical Research Site
Chicago, Illinois, United States
RECRUITINGClinical Research Site
Kansas City, Kansas, United States
RECRUITINGClinical Research Site
Boston, Massachusetts, United States
RECRUITINGClinical Research Site
Ann Arbor, Michigan, United States
RECRUITINGClinical Research Site
Detroit, Michigan, United States
RECRUITINGClinical Research Site
Albuquerque, New Mexico, United States
RECRUITINGClinical Research Site
Greensboro, North Carolina, United States
RECRUITING...and 3 more locations
Incidence and nature of participant TEAEs, SAEs, and AEs leading to discontinuation
Time frame: Baseline, Week 16
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