Study of Platelet Population Changes Under Circulatory Support With ECMO

University Hospital, Strasbourg, France75 enrolled

Overview

Advances in flow cytometry techniques have led to a better understanding of platelet phenotypes and have revealed the existence of four major platelet populations with distinct functional properties (native, proaggregating, procoagulating, or apoptotic). These phenotypes have a significant impact on the hemostatic capacity of blood platelets, and a proportional change in these populations during ECMO treatment could, at least in part, contribute to the observed complications.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiac Failure Respiratory Failure

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patient (≥18 years) treated in one of the intensive care units of the Anesthesia and Intensive Care Department at Strasbourg University Hospital. * Implanted with veno-arterial or veno-venous ECMO within the previous 24 hours. Exclusion Criteria: * Subject who has expressed their opposition to participating in the study. * Subject under legal protection. * Subject under guardianship or curatorship.

Locations (1)

Service d'anesthésie-réanimation - CHU de Strasbourg - France

Outcomes

Primary Outcomes

Proportional Changes in the Different Platelet Populations (native, proaggregating, procoagulant, or apoptotic)

Proportional Changes in the Different Platelet Populations (native, proaggregating, procoagulant, or apoptotic) on Days 1, 3, and 7 after the initiation of ECMO treatment.

Time frame: Days 1, 3, and 7 after the initiation of ECMO treatment.