Clindamycin as Antimicrobial Treatment for Streptococcus Spp. PeRiprosthetic Infection

University Hospital, Strasbourg, France260 enrolled

Overview

Clindamycin is an antibiotic with several advantages: high oral bioavailability and good bone and joint penetration. In France, it is a recommended drug for other types of Streptococcus spp. osteoarticular infections and can be used as an alternative to amoxicillin for periprosthetic infections, including when implants are retained. The hypothesis of this study is that clindamycin is no less effective than other drugs commonly used to treat periprosthetic Streptococcus spp. infections. The primary objective of this study is to evaluate the success rate of Streptococcus spp. periprosthetic joint infections treated with clindamycin compared to other antibiotic treatments.

Study Type

OBSERVATIONAL

Enrollment

260

Conditions

Streptococcus Infection

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patient (aged 18 years or older) at the time of surgery for infection * Probable or proven periprosthetic infection with Streptococcus spp. according to EBJIS diagnostic criteria * Patient operated on in one of the associated centers between 2013 and 2024 Exclusion Criteria: * Patient who underwent joint resection or amputation * Patient who was treated with suppressive antibiotic therapy (defined as antibiotic treatment lasting more than 6 months) which was decided upon prior to surgery

Locations (1)

Outcomes

Primary Outcomes

Therapeutic success of the medical-surgical strategy

Therapeutic success of the medical-surgical strategy defined as: patient showing no clinical signs of infection, no need for repeat surgery one year after the end of antibiotic treatment, and no repeat antibiotic treatment.

Time frame: One year after the end of antibiotic treatment