This is a prospective observational study to be conducted in intensive care units of Global South countries. Patients on mechanical ventilation for more than 12 hours who have initiated the weaning process and for whom the attending team plans extubation within the next 6 hours will be included. Data will be collected for each patient during the first 7 days after extubation, with follow-up until hospital discharge or death. We plan to conduct the study in intensive care units from Global South countries (low- and middle-income countries predominantly located in the Southern Hemisphere, though some in the Northern Hemisphere are also considered).
Study Type
OBSERVATIONAL
Enrollment
900
Extubation failure within 7 days.
Defined as reintubation or death within 7 days after extubation.
Time frame: 7 days.
Extubation within 28 days.
Defined as extubation within 28 days after first separation attempt.
Time frame: 28 days.
Intensive care unit length of stay.
Defined as the number of days from the time of first separation attempt until discharge from the intensive care unit.
Time frame: At intensive care unit discharge, up to 28 days.
Hospital length of stay.
Defined as the number of days from the time of first separation attempt until discharge from the hospital.
Time frame: At hospital discharge, up to 28 days.
Reintubation or death within 28 days.
Defined as composite criterion of reintubation or death within 28 days after first separation attempt.
Time frame: 28 days.
Intensive care unit mortality.
Defined as mortality from the time of first separation attempt until discharge from the intensive care unit.
Time frame: At intensive care unit discharge, up to 28 days.
Hospital mortality.
Defined as mortality from the time of first separation attempt until discharge from the hospital.
Time frame: At hospital discharge, up to 28 days.
Number of spontaneous breathing trials.
Defined as the number of spontaneous breathing trials performed after first separation attempt.
Time frame: 28 days.
WIND classification.
Group 1 (short weaning): the first separation attempt resulted in a termination of the weaning process within 24 hours (successful separation or early death). • Group 2 (difficult weaning): weaning was terminated after more than 1 day but in less than 1 week after the first separation attempt (successful separation or death). • Group 3 (prolonged weaning): weaning was still not terminated 7 days after the first separation attempt (by success or death).
Time frame: 28 days.
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