The Effect of Photobiomodulation on Microvascular Blood Flow: The Role of Wavelength and Skin Temperature

N/AEnrolling By InvitationNCT07338695

Afeka, The Tel-Aviv Academic College of Engineering40 enrolled

Overview

The objective of this study is to assess peripheral microcirculatory hemodynamic responses to photobiomodulation in participants with normal circulation and with functional peripheral vasoconstriction, using noninvasive thermography, photoplethysmography, and laser Doppler flowmetry.

This is a within-subject experimental study in which each participant completes two study sessions. Microvascular and systemic variables are continuously monitored in response to photobiomodulation delivered at either a blue or near-infrared wavelength, with each wavelength applied in a separate session. Each session includes a baseline period with controlled breathing, followed by photobiomodulation and a 20-minute post-intervention follow-up period. Peripheral microcirculatory responses are assessed using noninvasive thermography, photoplethysmography, and laser Doppler flowmetry.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Microcirculation

Interventions

Photobiomodulation - Blue WavelengthDEVICE

Photobiomodulation delivered at a blue wavelength (400-500 nm) to the hands during a single study session as part of a randomized crossover design.

Photobiomodulation - Near InfraredDEVICE

Photobiomodulation delivered at a near-infrared wavelength (780-1100 nm) to the hands during a single study session as part of a randomized crossover design.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Healthy males and females, between 20 and 75 years of age. 2. Willing to sign informed consent. 3. Willing to participate in two separate sessions, one for each wavelength. 4. Able to avoid caffeine and alcohol for at least 3 hours before each session. 5. Able to sit comfortably with both hands at heart level for the full measurement duration. Exclusion Criteria: 1. Currently smoking 2. Any abnormal skin condition in the area of light irradiation. 3. Pregnant, having given birth less than 3 months ago, and/or breastfeeding. 4. History of photosensitive conditions or use of photosensitizing medications 5. Suffering from significant concurrent illness, such as cardiac disorders or pertinent neurological disorders. 6. As per the Investigator's discretion, any physical or mental condition that might make it unsafe for the subject to participate in this study.

Locations (1)

Afeka, Tel-Aviv Academic College of Engineering

Tel Aviv, Israel

Outcomes

Primary Outcomes

Capillary blood flow

Capillary blood flow, expressed as red blood cell flux (perfusion units), measured continuously using laser Doppler flowmetry (≥10 Hz sampling rate) from baseline through the end of each study session.

Time frame: Up to 1 hour

Secondary Outcomes

Temperature distribution over hands measured by thermography

Thermal images will be acquired using a FLIR infrared camera, and spatial temperature distribution over the hands will be analyzed. Images will be acquired at one-minute intervals from baseline through the end of each study session.

Time frame: Up to 1 hour

Data from ClinicalTrials.gov

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