This study evaluated the antibody persistence of Chinese children five years after they received four doses of sIPV, two doses of MMR vaccine and one dose of HepA-L vaccine.
This is a follow-up study of several previous clinical trials (A Randomized, Controlled, Multicenter Phase 4 Clinic Trial to Evaluate the Immunogenicity and Safety of Combined Immunization of Sabin-strain Inactivated Polio Vaccine (sIPV), Diphtheria, Tetanus, Pertussis Vaccine (DTaP) and Measles, Moms and Rubella Vaccine (MMR) : NCT04054882, NCT04638985; A Randomized, Controlled, Multicenter Phase 4 Clinic Trial to Evaluate the Safety and Immunogenicity of Combined Immunization of Sabin-strain Inactivated Polio Vaccine (sIPV), Diphtheria, Tetanus, Pertussis (DTaP) Vaccine and Live Attenuated Hepatitis A Vaccine (HepA): NCT04053010, NCT04636827). Five years after vaccination with sIPV, MMR or HepA-L, blood samples were collected from the followed-up children to assess the antibody levels and seropositive rates against polio, measles, rubella, mumps and hepatitis A. This study was conducted in six provinces of China.
Study Type
OBSERVATIONAL
Enrollment
600
Si County Center for Disease Control and Prevention
Suzhou, Anhui, China
Feixiang District Center for Disease Control and Prevention
Handan, Hebei, China
Sheyang County Center for Disease Control and Prevention
Yancheng, Jiangsu, China
Chenggu County Center for Disease Control and Prevention
Hanzhong, Shaanxi, China
seropositive rates of antibodies against poliovirus
The percentage of participants with positive antibody(titre ≥ 8) against all three serotypes of poliovirus 5 years after the four doses of sIPV immunization.
Time frame: 5 years after the four doses of sIPV immunization
seropositive rates of antibodies against measles, rubella, mumps
The percentage of participants with positive antibody against measles, rubella, mumps 5 years after the two doses of MMR immunization.
Time frame: 5 years after the two doses of MMR immunization
seropositive rates of antibodies against hepatitis A
The percentage of participants with positive antibody against hepatitis A 5 years after the one doses of HepA-L immunization.
Time frame: 5 years after the one doses of HepA-L immunization
GMTs of antibodies against poliovirus
The GMTs of participants against all three serotypes of poliovirus 5 years after the four doses of sIPV immunization.
Time frame: 5 years after the four doses of sIPV immunization
GMCs of antibodies against measles, rubella, mumps
The GMCs of participants against measles, rubella, mumps 5 years after the two doses of MMR immunization.
Time frame: 5 years after the two doses of MMR immunization
GMCs of antibodies against hepatitis A
The GMCs of participants against hepatitis A 5 years after the one doses of HepA-L immunization.
Time frame: 5 years after the one doses of HepA-L immunization
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Yanhu District Center for Disease Control and Prevention
Yuncheng, Shanxi, China
Jiangyou Center for Disease Control and Prevention
Mianyang, Sichuan, China