Comparison of Oral vs Intravenous Iron Therapy for the Treatment of Postpartum Anemia

Shahida Islam Medical Complex122 enrolled

Overview

Postpartum anemia is a common condition associated with adverse maternal outcomes. This study aimed to compare the effectiveness of oral iron therapy versus intravenous iron therapy in women with postpartum anemia.

This randomized, open-label, parallel-group study was conducted at Shahida Islam Medical College and Hospital, Lodhran, Pakistan. Women diagnosed with postpartum anemia who fulfilled the eligibility criteria were randomly allocated using a lottery method to receive either intravenous iron (ferric carboxymaltose) or oral iron therapy (ferrous sulfate). The primary outcome was the change in hemoglobin level from baseline to 6 weeks of follow-up.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

122

Conditions

Postpartum Anaemia

Interventions

Ferric Carboxy MaltoseDRUG

Participants received Intravenous iron i.e ferric carboxymaltose (≤1,000 mg) were given to patients in Group "A" either as a single dose or as two doses spaced three days apart in 100 milliliters of 0.9% normal saline during a half-hour period.

Ferrous SulfateDRUG

Participants given tablet Ferrous sulfate, 325 mg orally three times a day.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. All women with postpartum anaemia as per operational definition i.e Haemoglobin \<11 g/dl at 24 hours after delivery (either caesarean or SVD). 2. Age 20-40 years. 3. BMI 19-25. 4. Pre-operative haemoglobin \>10 g/dl. 5. Both primiparous and multiparous. 6. Both primigravida and multigravida. \- Exclusion Criteria: 1. Iron Intolerance or previous history of allergy to iron 2. Parenteral Iron hypersensitivity 3. Patients with thalassemia 4. Indication of blood transfusion 5. Patients with bleeding/ clotting disorders 6. Patients with postpartum haemorrhage 7. Patients with chronic diseases.

Locations (1)

Shahida Islam Medical College and Hospital, Lodhran

Lodhrān, Punjab Province, Pakistan

Outcomes

Primary Outcomes

Change in hemoglobin level

Time frame: Baseline to 6 weeks postpartum

Data from ClinicalTrials.gov

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