Urinary NGAL and KIM-1 After ESWL

Marmara University50 enrolled

Overview

The goal of this prospective observational study is to evaluate the effect of different time intervals between extracorporeal shock wave lithotripsy (ESWL) sessions on renal injury using urinary biomarkers in patients with urinary system stone disease. The main questions it aims to answer are: Does the interval between consecutive ESWL sessions affect the degree of renal injury? Are urinary NGAL and KIM-1 levels reliable biomarkers for detecting ESWL-related renal damage? What is the optimal time interval between ESWL sessions to minimize renal injury? If there is a comparison group, researchers will compare patients undergoing ESWL with different inter-session time intervals to determine whether shorter or longer intervals are associated with higher levels of renal injury biomarkers. Participants will: Undergo ESWL treatment for urinary system stones Be assigned to one of two groups based on the time interval between ESWL sessions Provide urine samples before ESWL and after three ESWL sessions Have urinary NGAL and KIM-1 levels measured to assess renal injury

Study Type

OBSERVATIONAL

Enrollment

Conditions

Urinary Stone Renal Injury

Interventions

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged 18 years and older * Patients with an indication for extracorporeal shock wave lithotripsy (SWL) for urinary system stone disease Exclusion Criteria: * Positive nitrite on urinalysis prior to SWL * Positive urine culture prior to SWL, defined as \>10⁵ CFU/mL bacterial growth * Suspected struvite stone, based on previous or partial stone analysis * Presence of a nephrostomy tube * Presence of urinary diversion * History of bleeding disorders * Pregnancy * Use of anticoagulant therapy * History of cardiac arrhythmia

Outcomes

Primary Outcomes

Change in urinary NGAL level

Difference in urinary NGAL levels measured before SWL and after completion of three SWL sessions

Time frame: Within 2 weeks after completion of the third SWL session

Change in urinary KIM-1 levels

Difference in urinary KIM-1 levels measured before SWL and after completion of three SWL sessions

Time frame: Within 2 weeks after completion of the third SWL session

Secondary Outcomes

Between-group difference in change of urinary NGAL and KIM-1 levels according to SWL session intervals

Time frame: Within 2 weeks after completion of the third SWL session

Urinary NGAL and KIM-1 After ESWL

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes