This will be a randomized double-blind placebo controlled clinical trial to determine if supplementing with essential amino acids (EAAs) for two weeks prior to, and 3 months after corrective spinal surgery in adults with spinal deformity can stimulate greater muscle protein turnover and whole-body protein balance, and enhance recovery after surgery when compared to a calorie matched placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Enrollment
20
This intervention will be EAA supplementation of 15g twice a day for two weeks before surgery and then 12 weeks post-surgery in individuals diagnosed with ASD
Placebo
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Muscle Protein Synthesis
Mixed muscle protein synthesis expressed as the fractional synthetic rate.
Time frame: 24 hours
Body Composition
Body composition via DEXA will be used to examine lean body mass, fat mass, and bone mineral density. Bioelectrical impedance analysis will be used to determine total body water and muscle quality
Time frame: 12 weeks
Handgrip Strength & Walking Ability
Hand grip strength in kg and 6-min walk test ability will be examined
Time frame: 12 weeks
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