Mining the Gut Microbiota of Adults for Health-relevant Microbial Signatures.

Zhujiang Hospital1,530 enrolled

Overview

Mining the gut microbiota of adults for health-relevant microbial signatures.

This study is a community-based, observational cross-sectional investigation, enrolling 1,530 middle-aged and elderly volunteers. Data were collected through a systematic, multi-dimensional assessment, which included: Biospecimen Collection: Blood, urine, and stool samples were obtained from the volunteers. Physical and Imaging Examinations: Procedures included anthropometric measurements, vital sign monitoring, oral examinations, electrocardiograms, physical examinations of key organs, and abdominal ultrasonography. Psychological and Cognitive Assessments: Standardized scales were administered to assess anxiety/depression and memory function. All clinical and questionnaire data were processed through standardized procedures, forming a comprehensive health database for subsequent analysis.

Study Type

OBSERVATIONAL

Enrollment

1,530

Conditions

Adult

Interventions

Observational, non-interventional study.OTHER

Observational, non-interventional study.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 95 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria： * Community-dwelling adults aged 30 to 95 years. * Individuals who underwent an annual health examination at the Health Management Center of Huzhou Central Hospital during the specified time period. * Ability to comprehend the study content and voluntarily provide signed informed consent. * Willingness and ability to provide the required biospecimens (blood, urine, stool). Exclusion Criteria: * Concurrent participation in another interventional clinical trial that is likely to interfere with the results of this study. * Voluntary withdrawal from the study.

Locations (1)

Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, China

Outcomes

Primary Outcomes

Identification of Health-Relevant Signatures in Adults

Primary Outcome Measure 1)Change in standard laboratory parameters from baseline:Changes in routine laboratory parameters measured in blood, urine, and stool samples, including complete blood count and standard serum biochemistry panels.Unit of Measure: Various laboratory units (e.g., g/L, U/L, mmol/L); 2) Change in anthropometric measurements from baseline: Anthropometric measurements including body weight (kg), height (m), and body mass index (BMI, kg/m²).Unit of Measure:kg, m, kg/m²; 3) Alcohol consumption status: Alcohol consumption status assessed by self- report, categorized as current drinker or non-drinker at enrollment.Unit of Measure:Categorical (yes/no); 4) Hospital Anxiety and Depression Scale (HADS) scores: Anxiety and depression symptom severity assessed using the Hospital Anxiety and Depression Scale, including anxiety and depression subscale scores.Unit of Measure:Score on a standardized scale.

Time frame: Baseline

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.