This study aims to explore how early time-restricted eating (eTRE) - where all daily meals are eaten within a specific time window - affects health and quality of life in adults. The researchers will compare results between adults with mild, well-controlled asthma and adults without asthma (the control group). Participants can continue to eat their normal food; only the timing of meals will change.
During the study, participants will be asked to: * Follow an early time-restricted eating schedule for one week and their usual eating schedule for another week while keeping to their usual diet and physical activity. * Attend four visits to the research facility on campus. * Provide saliva, blood, and urine samples for health marker analysis. * Complete breathing tests (spirometry and FeNO) to measure lung function. * Complete short questionnaires about physical activity and quality of life. * Take part in a short interview about their asthma symptoms and quality of life. * Keep a brief food diary each week. * Provide details of any medications they currently take.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
36
The participants who are assigned to eTRE will be asked to eat from 8 am to 4 pm without restriction on the quantity or amount of food and fast for the rest of the time except for drinking water for one week. After two weeks washout period, participants will be asked to follow their habitual diet for one week.
The participants will be asked to follow their habitual diet for one week. After two weeks washout period, the participants will be assigned to eTRE and asked to eat from 8 am to 4 pm without restriction on the quantity or amount of food and fast for the rest of the time except for drinking water for one week.
Health and Life Science
Leicester, England, United Kingdom
Lung Function Parameters, FEV1 in Liters (L)
A spirometry test will be conducted to gather information about lung function parameters.
Time frame: At baseline and after 1 week in each study arm
Lung Function Parameters, FVC in Liters (L)
A spirometry test will be conducted to gather information about lung function parameters.
Time frame: At baseline and after 1 week in each study arm
Lung Function Parameters, FEV1/ FVC ratio
A spirometry test will be conducted to gather information about lung function parameters.
Time frame: At baseline and after 1 week in each study arm
Fractional Exhaled Nitric Oxide (FeNO) in parts per billion (ppb)
Fractional exhaled nitric oxide (FeNO) test will be conducted to gather information about airway inflammation.
Time frame: At baseline and after 1 week in each study arm
Blood for health biomarkers
Changes in plasma-based health biomarkers will be assessed from acellular plasma extracted from venous blood samples to explore physiological responses to the intervention. Biomarker results will be summarized descriptively.
Time frame: At baseline and after 1 week in each study arm
Urinary Biomarker Profile
The urinary metabolomic profile will be assessed to explore changes in metabolites associated with the intervention. Results will be summarized descriptively.
Time frame: At baseline and after 1 week in each study arm
Salivary Metabolomic Profile
Salivary metabolomic profile will be assessed to explore changes in metabolites associated with the intervention. Metabolomic features will be summarized descriptively.
Time frame: At baseline and after 1 week in each study arm
body weight in kilograms (Kg)
Calibrated electronic scales will be used to measure body weight in kilograms.
Time frame: At baseline and after 1 week in each study arm
Height in meters (m)
A stadiometer will be used to measure height in meters.
Time frame: At baseline and after 1 week in each study arm
Demographic Data
Demographic data such as age, sex and ethnicity.
Time frame: At baseline
Changes in Quality of Life using Asthma Quality of Life Questionnaire (AQLQ)
The Asthma Quality of Life Questionnaire (AQLQ) will be given to assess changes in quality of life in individuals with asthma.
Time frame: At baseline and after 1 week in each study arm
Changes in Quality of Life using PROMIS Global Health v1.2
The PROMIS Global Health v1.2 will be given to assess changes in quality of life for individuals without asthma.
Time frame: At baseline and after 1 week in each study arm
Semi-structured interview for assessing quality of life and acceptability of interventions.
A semi-structured interview will be conducted among participants with mild asthma who are assigned to the eTRE group to assess the challenges they faced and their experiences after the eTRE intervention.
Time frame: After 1 week of eTRE
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