The primary objective of the study is to compare the rate of postoperative complications between rectal cancer patients undergoing standard neoadjuvant chemoradiotherapy or short- course radiotherapy and patients receiving TNT. The secondary objectives of the study include the evaluation of treatment-related adverse reactions and postoperative complications in elderly patients receiving the treatments and the comparison of treatment-related adverse reactions and postoperative complications in patients receiving induction versus consolidation TNT.
Study Type
OBSERVATIONAL
Enrollment
266
Comparing
IRCCS Humanitas Research Hospital
Rozzano, Milan, Italy
90 days postoperative complications
The primary endpoint of the study is the rate of 90-day postoperative complications between the study cohorts.
Time frame: 12 months
The primary endpoint of the study is the rate of 90-day postoperative complications between the study cohorts.
The primary endpoint of the study is the rate of 90-day postoperative complications between the study cohorts.
Time frame: 3 months
90 days severe postoperative complications between the cohorts
The rate of 90-day severe postoperative complications between the study cohorts.
Time frame: 12 months
90-day Comprehensive Complication Index
The median of the 90-day Comprehensive Complication Index (CCI) between the study cohorts.
Time frame: 12 months
Treatment-related adverse reactions
The rate of treatment-related adverse reactions between the study cohorts.
Time frame: 12 months
Severe treatment-related adverse reactions
The rate of severe treatment-related adverse reactions between the study cohorts.
Time frame: 12 months
90-day postoperative complications between patients receiving neoadjuvant chemoradiotherapy,short-course radiotherapy, induction TNT, and consolidation TNT.
The rate of 90-day postoperative complications between patients receiving neoadjuvant chemoradiotherapy,short-course radiotherapy, induction TNT, and consolidation TNT.
Time frame: 12 months
Treatment-related adverse reactions between patients receiving neoadjuvant chemoradiotherapy,short-course radiotherapy, induction TNT, and consolidation TNT
The rate of treatment-related adverse reactions between patients receiving neoadjuvant chemoradiotherapy,short-course radiotherapy, induction TNT, and consolidation TNT.
Time frame: 12 months
The rate of 90-day postoperative complications between the two cohorts in a sub-population of elderly patients
The rate of 90-day postoperative complications between the two cohorts in a sub-population of elderly patients (≥ 70 years old at the time of diagnosis).
Time frame: 12 months
The rate of treatment-related adverse reactions between the study cohorts in a sub-population of elderly patients
The rate of treatment-related adverse reactions between the study cohorts in a sub-population of elderly patients (≥ 70 years old at the time of diagnosis).
Time frame: 12 months
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