Mechanism Study of G Protein-coupled Receptor 81 in Multiple Organ Dysfunction of Heat Stroke

N/ANot Yet RecruitingNCT07346443

Second Affiliated Hospital of Wenzhou Medical University100 enrolled

Overview

Heat stroke is one of the common acute and critical conditions in the ICU, characterized by a high incidence and mortality rate, and there is still a lack of effective and precise treatment methods. The latest research indicates that G protein-coupled receptor 81 (GPR81), as an endogenous receptor of lactic acid, can regulate immune responses by up-regulating the expression of inflammatory factors and the chemotaxis of neutrophils, suggesting that the GPR81 receptor may play a potential key role in heat stroke. The investigators aim to reveal the position and key role of GPR81 in improving multiple organ dysfunction caused by heat stroke, and to clarify its specific molecular mechanism, with the goal of providing new ideas for the prevention and treatment of heat stroke based on lactate levels, a commonly used clinical indicator.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Heat Stroke

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * 1\) There was a clear history of high-temperature exposure before the onset of the disease; 2) Core body temperature ≥40℃ upon admission or within 2 hours of onset; 3) At least one abnormal symptom of the central nervous system occurs 4) Sign an informed consent form or have their legal representative agree to participate in the research. Exclusion Criteria: * 1\) Suffering from central nervous system diseases; 2) Long-term use of anticoagulants; 3) Those who refuse to participate or withdraw their informed consent.

Outcomes

Primary Outcomes

The 28-day survival rate of patients with heat stroke

For patients with heat stroke, if they die within 28 days, it indicates they are non-survivors; if they do not die within 28 days, it indicates they are survivors

Time frame: Survival status will be assessed over a period of up to 28 days, starting from the date of hospital admission.

Secondary Outcomes

Plasma lactate levels in patients with heat stroke

Collect the plasma lactic acid level each time when patients with heat stroke are hospitalized

Time frame: Plasma lactate levels will be measured at admission and then daily during the hospital stay, for a period of up to 28 days.