Radiotherapy Safety for Liver Malignancies Using Post-Treatment Imaging

Cao peiguo274 enrolled

Overview

The goal of this retrospective observational study is to investigate the safety of radiation therapy for liver malignancies by analyzing data from patients who have already completed this treatment . The main questions it aims to answer are: What is the specific radiation dose level that leads to a visible change on CT scans called a Focal Liver Reaction (FLR)? Why do some patients develop these imaging changes while others do not, based on their scan features and clinical information? Researchers will compare patients who developed FLR with those who did not to identify the factors associated with this reaction. This study uses existing medical records and images; therefore, participants will not need to undergo any new interventions or procedures.

Study Type

OBSERVATIONAL

Enrollment

274

Conditions

Liver Neoplasms Radiation-Induced Liver Injury

Interventions

Clinically Delivered Radiation Therapy (e.g., SBRT/IMRT) for Liver Cancer

This is a retrospective observational study. The intervention (radiotherapy) was administered as part of standard clinical care prior to the study. Researchers are analyzing the outcomes of this previously delivered intervention.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Primary or secondary liver malignancies, including hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and secondary liver tumors. * Liver function of Child-Pugh classification A or B. * Completed EBRT treatment as planned. * No other local treatment of liver lesions between EBRT and the follow-up imaging examination. * Complete imaging re-examination data. * Three-phase enhancement CT scans showing typical Focal Liver Reaction (FLR). * The registration effect of follow-up CT and planning CT is satisfactory. Exclusion Criteria: * History of upper abdominal radiotherapy or liver transplantation. * Failure to complete radiotherapy as scheduled. * Previous cancer treatment-related toxicities that did not return to baseline or grade 0-1 (except for hair loss and peripheral neuropathy).

Outcomes

Primary Outcomes

Dose Threshold for Focal Liver Reaction (FLR)

The minimum radiation dose (in Gy) required to induce a radiologically visible Focal Liver Reaction (FLR) on follow-up CT imaging, as assessed by CT scan.

Time frame: Retrospectively, data collected from the beginning of radiotherapy to one year after the end of radiotherapy

Predictors of FLR Susceptibility

Differences in radiomic features and clinical baseline characteristics (e.g., age, gender, liver function, and tumor size) between patients with radiologically confirmed Focal Liver Reaction (FLR) and those without, assessed by radiomic analysis and clinical data review.