Reversal of Roux-en-Y Gastric Bypass: A Swedish National Cohort Study

N/AActive Not RecruitingNCT07347093

Vrinnevi Hospital199 enrolled

Overview

Objective: To investigates incidence, indications, symptom relief, complications, and weight outcomes after Roux-en-Y gastric bypass (RYGB) reversal. Background: RYGB is an effective treatment for obesity, but in rare cases may be associated with severe long-term complications requiring RYGB reversal. Evidence on incidence and outcomes is limited. Methods: This nationwide, multi-center, retrospective cohort study included all patients undergoing RYGB reversal in Sweden between 2007 and 2023. Data were obtained from the Scandinavian Obesity Surgery Registry (SOReg) and medical records.

Study Type

OBSERVATIONAL

Enrollment

199

Conditions

Gastric Bypass Surgery Revisional Bariatric Surgery Complications After Bariatric Surgery

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (≥ 18years) who underwent reversal of RYGB between 2007 and 2023. Exclusion Criteria: * Emergency reversal due to bowel ischemia * Reversal following other bariatric procedures (e.g. gastric banding) * Partial/functional reversals (e.g., gastro-gastric fistula or anastomosis between the Roux-limb and gastric remnant, without full reversal of RYGB)

Locations (1)

Outcomes

Primary Outcomes

Symptom relief

Symptom relief is classified as no, partial, or complete improvement. Complete improvement was defined as full resolution of the index symptom (e.g., cessation of hypoglycemia, pain-free status without analgesics). Partial improvement denoted a clinically meaningful reduction in symptom severity or frequency that did not meet criteria for complete resolution. No improvement indicated persistent symptoms.

Time frame: Through study completion, an average of 2 years.

Secondary Outcomes

Indications for surgery

Indications are categorized as abdominal pain, malnutrition, gastrointestinal symptoms, post-bariatric hypoglycemia, and psychological distress, and reported as number (frequencies).

Time frame: Through study completion, an average of 2 years.

Weight outcome after surgery

Weigth \[in kilograms\] will be reported at baseline (before surgery), at one year follow-up, and two-year follow-up.

Time frame: Through study completion, an average of 2 years.

Complications

Complications after surgery are registered as any complication and major complication (defined as Clavien-Dindo classification \>=3b), presented as number (frequencies).

Time frame: At 30-day follow-up and one-year follow-up after surgery.

Height

Height (in meters) will be used to report BMI (in kg/m2).

Time frame: Through study completion, an average of 2 years

BMI

Weight (in kilograms) and height (in meters) will be combined to report BMI (in kg/m2) at baseline (before surgery), at one year follow-up, andat two-year follow-up.

Time frame: Through study completion, an average of 2 years.