The goal of this observational study is to learn about the long-term effects of radiotherapy for people who were treated for non-melanoma skin cancer (NMSC) in the head and neck area. The study focuses on adults who finished radiotherapy at least two years ago. The main questions we aim to answer are: How satisfied are participants with the cosmetic result of their treatment? What skin changes do healthcare professionals observe at the treated area? How many participants have experienced a recurrence or developed a new skin cancer, since treatment? Participants will be invited to: Attend one extra hospital visit at least two years after they finished radiotherapy Answer a short questionnaire about their cosmetic satisfaction Have their skin examined, including photos and dermatoscopy The results may help improve future treatment guidelines for people with non-melanoma skin cancer.professional, and any local recurrences will be identified through national health registries. This nationwide study (DOSCA-2) will provide real-world data to help guide future treatment recommendations for NMSC.
Study Type
OBSERVATIONAL
Enrollment
2,900
In Denmark, people treated with primary radiotherapy for NMSC are not routinely offered a hospital follow-up visit to evaluate cosmetic results or recurrence. In this study, patients who received radiotherapy between 2020 and 2024 at five Danish cancer centers will be invited for a clinical examination at least two years after treatment. Cosmetic outcome will be rated by both the patient and a health professional, and any local recurrences will be identified through national health registries.
Aarhus University Hospital
Aarhus N, Denmark
Cosmetic outcome
The primary outcome is cosmetic outcome, assessed by both the patient and a health professional using the LENT-SOMA criteria.
Time frame: At least 2 years after completion of primary radiotherapy for NMSC
Local recurrence
Identified through the Danish Pathology Registry and follow-up visit
Time frame: At least 2 years after completion of primary radiotherapy for NMSC
Effect of Tumour Histology
Differences in risk of recurrence between basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) will be analyzed.
Time frame: At least 2 years after completion of radiotherapy
Comparison between Short-Course and Long-Course Radiotherapy Regimens
Differences in risk of recurrence between the treatment regimens will be analyzed.
Time frame: At least 2 years after completion of radiotherapy
Effect of Tumour Histology
Differences in cosmetic outcome between basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) will be analyzed
Time frame: At least 2 years after completion of radiotherapy
Comparison between Short-Course and Long-Course Radiotherapy Regimens
Differences in cosmetic outcome between the treatment regimens will be analyzed.
Time frame: At least 2 years after completion of radiotherapy.
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