Acne vulgaris is a common chronic inflammatory skin condition that can significantly affect quality of life. Standard treatments such as topical retinoids are effective but may not fully control symptoms in all patients. This study evaluated the effectiveness of auricular acupressure combined with topical 0.1% adapalene compared with topical 0.1% adapalene alone in patients with acne vulgaris. Auricular acupressure is a non-invasive traditional medicine technique that may help regulate inflammatory responses and improve skin conditions. The objective of this study was to determine whether the combination therapy provides greater improvement in acne severity and clinical outcomes than standard topical treatment alone.
Acne vulgaris is a multifactorial inflammatory skin disease commonly affecting adolescents and young adults. Although topical retinoids such as adapalene are widely used and effective, some patients experience incomplete responses or persistent symptoms. Auricular acupressure is a traditional therapeutic method that involves stimulating specific points on the ear and has been used to support systemic regulation and inflammatory control. This study was designed to explore the potential added benefit of auricular acupressure when combined with standard topical adapalene therapy. This interventional study compared two treatment approaches in patients with acne vulgaris: auricular acupressure combined with topical 0.1% adapalene versus topical 0.1% adapalene alone. Participants were assigned to treatment groups according to the study protocol and followed for clinical assessment. The primary objective of the study was to evaluate the effectiveness of the combination therapy in improving acne severity and overall clinical outcomes compared with standard treatment alone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
64
Auricular acupressure was performed by applying pressure to specific auricular points according to traditional medicine principles. The intervention was administered as an adjunctive therapy in combination with topical adapalene.
Topical adapalene 0.1% was applied to affected areas once daily as standard treatment for acne vulgaris.
Le Van Thinh Hospital
Ho Chi Minh City, Ho Chi Minh City, Vietnam
Change in Global Acne Grading System (GAGS) score
The Global Acne Grading System (GAGS) was used to assess acne severity. The total GAGS score was calculated at baseline and at the end of treatment. The primary outcome was the change in GAGS score from baseline to the end of treatment, and comparisons were made between the two study groups.
Time frame: From baseline to week 4
Change in inflammatory and non-inflammatory acne lesion counts
The number of inflammatory lesions (papules and pustules) and non-inflammatory lesions (open and closed comedones) was recorded at baseline and weekly during treatment. The secondary outcome was the change in lesion counts from baseline to week 4 between the two treatment groups.
Time frame: From baseline to week 4
Change in Dermatology Life Quality Index (DLQI) score
Quality of life was assessed using the Dermatology Life Quality Index (DLQI), a validated questionnaire consisting of 10 items. The secondary outcome was the change in DLQI score from baseline to week 4, comparing the two study groups.
Time frame: From baseline to week 4
Incidence of treatment-related adverse events
Adverse events were monitored throughout the study period, including skin dryness, burning sensation, itching, erythema, and other local or systemic reactions. The frequency and type of adverse events were recorded and compared between groups.
Time frame: During the 4-week treatment period
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