Serum and Salivary Cortisol Assessment in Patients With Adrenal Incidentalomas and Healthy Controls

Inclusion Criteria (patients): * age ≥ 18 years, a new diagnosis of an adrenal incidentaloma (defined as an adrenal mass \> 1 cm detected when using diagnostic imaging for non-related reasons). Inclusion Criteria (controls): * age ≥ 18 years, no previous history of conditions involving the adrenal glands Exclusion Criteria (patients): * active cancer; an adrenal incidentaloma suspected of malignancy; bilateral adrenal incidentalomas; pregnancy and breastfeeding; conditions or medical treatments that interfere with dexamethasone metabolism and cortisol metabolism/measurements; severe comorbidities; chronic kidney disease (defined as an estimated glomerular filtration rate \< 60 ml/min); and inability to provide written informed consent. Exclusion Criteria (controls): * active cancer; pregnancy and breastfeeding; conditions or medical treatments that interfere with dexamethasone metabolism and cortisol metabolism/measurements; severe comorbidities; chronic kidney disease (defined as an estimated glomerular filtration rate \< 60 ml/min); and inability to provide written informed consent.