A Novel 532-nm Picosecond Laser for Freckle Treatment in Chinese Patients

Inclusion Criteria: * Aged 18 to 65 years (inclusive). * Fitzpatrick skin type III, IV, or V. * Diagnosed with facial freckles. * Presence of visually symmetrical bilateral facial freckles. * Able to understand and voluntarily sign the informed consent form. * Willing and able to comply with all study procedures and follow-up visits. Exclusion Criteria: * High photosensitivity to any light spectrum. * Severe organic diseases (e.g., epilepsy, psychosis). * History of sunburn within the past 1 month. * History of skin malignancies (e.g., squamous cell carcinoma, melanoma). * Skin lesions that are broken, inflamed, or with a history of poor wound healing or keloids. * Diagnosis of cutaneous lupus erythematosus. * Significant systemic disease or obvious lesions in the treatment area. * Presence of herpes simplex virus (HSV) in the expected treatment area. * Active local or systemic infection, or open wounds in the treatment area. * History of immunosuppression/immunodeficiency (including HIV/AIDS) or use of immunosuppressive drugs. * Use of anticoagulants or medications that may alter wound healing within the past 1 month. * Use of known photosensitizing medications within the past 1 month. * Oral isotretinoin (Accutane) use within 12 months prior to initial treatment or planned use during the study. * Use of iron supplements, herbal supplements (e.g., Ginkgo, Ginseng, Garlic), or fish oil supplements within the past 1 month. * Other photo or energy-based aesthetic procedures in the treatment area within the past 1 month. * Pregnancy, lactation, or planning pregnancy during the study period. * Participation in another clinical trial (except registry studies) within 3 months prior to screening. * Considered by the investigator to have poor compliance or otherwise unsuitable for participation.