This 16-week, randomized, triple-blinded, placebo-controlled study evaluates the effects of an avocado dietary supplement (Metavo) on healthy weight and blood glucose management in overweight adults. The study includes body measurements, questionnaires, blood tests, and CGM monitoring to assess metabolic outcomes and participant-reported perceptions of well-being.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
Participants will take 8 Intervention capsules per day (4 in the morning, 4 in the afternoon)
Participants will take 8 placebo capsules per day (4 in the morning, 4 in the afternoon)
Citruslabs
Las Vegas, Nevada, United States
Change in Body Mass
Measured via Withings Smart Scale. Participants will weigh themselves daily for 3 consecutive days each week. If the first two values are similar, their average is used. If they differ by ≥10 lbs, the third value is used to determine the average.
Time frame: Baseline through Week 16
Change in Average Blood Glucose
Change in average blood glucose levels measured using a Continuous Glucose Monitor (CGM). Average glucose will be calculated over each time period and the change from pre-baseline to Weeks 14-16 will be reported.
Time frame: 2 weeks before Baseline and Weeks 14-16
Change in Hemoglobin A1C (HbA1C)
Assessed via blood samples at Labcorp or via home phlebotomy.
Time frame: Baseline and Week 16
Change in Fasting Insulin
Assessed via blood samples at Labcorp or via home phlebotomy.
Time frame: Baseline and Week 16
Change in Lipid Panel
Includes Cholesterol, LDL, VLDL, HDL, and triglycerides. Measured via Labcorp or home phlebotomy.
Time frame: Baseline and Week 16
Change in hs-CRP
High-sensitivity C-reactive protein measured via Labcorp or home phlebotomy.
Time frame: Baseline and Week 16
Change in Fasting GLP-1 Levels
Only measured in the home phlebotomy subgroup using InterScience Institute lab testing.
Time frame: Baseline and Week 16
Change in Waist Circumference
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Measured with a tape measure.
Time frame: Baseline, Week 2, Week 4, Week 8, Week 12, Week 16
Change in Time in Range (TIR)
Change in percentage of time that glucose levels are within the target range, measured using a CGM. TIR will be computed as the percentage of total CGM readings within the target range during the specified time periods.
Time frame: 2 weeks before Baseline and Weeks 14-16
Change in Time Below Range (TBR)
Change in percentage of time that glucose levels are below the target range, measured using a CGM. TBR will be calculated as the percentage of total CGM readings below the target range.
Time frame: 2 weeks before Baseline and Weeks 14-16
Change in Time Above Range (TAR)
Change in percentage of time that glucose levels are above the target range, measured using a CGM. TAR will be calculated as the percentage of total CGM readings above the target range.
Time frame: 2 weeks before Baseline and Weeks 14-16
Change in Quality of Life
Evaluated using the Short Form-12 (SF-12) questionnaire.
Time frame: Baseline, Week 2, Week 4, Week 8, Week 12, Week 16
Change in Physical Activity
Evaluated using the Godin Leisure-Time Exercise Questionnaire (GLTE).
Time frame: Baseline, Week 2, Week 4, Week 8, Week 12, Week 16
Change in Eating Habits
Evaluated using the Three-Factor Eating Questionnaire - Revised 21 (TFEQ-R21).
Time frame: Baseline, Week 2, Week 4, Week 8, Week 12, Week 16
Change in Food Cravings
Evaluated using the Food Craving Questionnaire - Trait reduced (FCQ-T reduced).
Time frame: Baseline, Week 2, Week 4, Week 8, Week 12, Week 16
Change in Self-Reported Mood, Energy, and Health
Participants report changes in energy levels, weight perception, mood, and general well-being.
Time frame: Baseline, Week 2, Week 4, Week 8, Week 12, Week 16
Change in Total Muscle Mass (kg)
Total skeletal muscle mass measured in kilograms using a Withings smart scale via Bioelectrical Impedance Analysis (BIA).
Time frame: Weekly from Baseline to Week 16
Change in Total Body Fat Mass (kg)
Total weight of body fat measured in kilograms using a Withings smart scale via Bioelectrical Impedance Analysis (BIA).
Time frame: Weekly from Baseline to Week 16
Change in Bone Mass (kg)
Estimated weight of bone mineral content in kilograms, measured using a Withings smart scale via Bioelectrical Impedance Analysis (BIA).
Time frame: Weekly from Baseline to Week 16
Change in Total Lean Mass (kg)
Total fat-free mass (including muscle, bone, and water) measured in kilograms using a Withings smart scale via Bioelectrical Impedance Analysis (BIA).
Time frame: Weekly from Baseline to Week 16
Change in Total Body Water Percentage (%)
Total body water as a percentage of total body weight, measured using a Withings smart scale via Bioelectrical Impedance Analysis (BIA).
Time frame: Weekly from Baseline to Week 16
Change in Visceral Fat Index
An indexed score representing the amount of visceral fat (the fat surrounding internal organs) measured via a Withings smart scale. This index typically ranges from 1 to 20, where higher scores indicate higher visceral fat levels.
Time frame: Weekly from Baseline to Week 16