Nanocrystalline Megestrol Acetate for Cachectic Stage Locally Advanced Hepatocellular Carcinoma

Inclusion Criteria: 1. Patients with hepatocellular carcinoma who have not previously received systemic therapy and are confirmed by histological or cytological assessment, as evaluated by the investigator, to be unsuitable or ineligible for curative surgical resection; Barcelona Clinic Liver Cancer (BCLC) stage B-C. 2. Child-Pugh class A or B7. 3. Planned to receive interventional therapy in combination with systemic antitumor therapy. 4. At least one measurable tumor lesion according to mRECIST v1.1. 5. Meet the diagnostic criteria for pre-cachexia or cachexia (based on the Fearon criteria). Exclusion Criteria: 1. Presence of any condition affecting gastrointestinal absorption, such as dysphagia, malabsorption, or uncontrolled vomiting; patients receiving tube feeding or parenteral nutrition. 2. Presence of anorexia due to anorexia nervosa, psychiatric disorders, or pain that makes eating difficult. 3. Patients with acquired immunodeficiency syndrome (AIDS). 4. Currently receiving or planning to receive other medications that increase appetite or body weight, such as corticosteroids (except short-term dexamethasone during chemotherapy), androgens, progestins, thalidomide, olanzapine, anamorelin, or other appetite stimulants. 5. Patients with Cushing's syndrome, adrenal or pituitary insufficiency, or poorly controlled diabetes mellitus.